The Plasma/Serum Generation Wafer series was developed specifically for the generation of plasma/serum from whole blood. While this application is quite prominent, these wafers can be used for a variety of other filtration applications by changing the membrane data and using a variety of pore sizes. For plasma generation wafers with 10 mm diameter membranes, each membrane can generate approximately 12-15 μl of plasma/serum from 25 μl of whole blood. Each unit of these wafers contains a (mini-)Luer interface (1) for blood loading, a support channel with a cross-section of 300 μm x 100 μm (2) for transferring blood at the top of the separating membrane (3) into the 10 mm diameter wafer-based chamber, a plasma/serum collection channel underneath the membrane (4), and a ventilation channel (5) also underneath the membrane with a cross-section of 100 μm x 100 μm. channel (5) also below the membrane. Vacuum is applied to the outside world through the collection channel and the second interface (6). The third interface (7) is closed during sample loading and helps to release a slight vacuum smoothly if the membrane pores are clogged with solid components of the blood (e.g., red blood cells, monocytes, platelets, or leukocytes). These wafers are supplied without (membrane wafer 168) or with additional venting tubes (membrane wafer 200) to more easily fill the membrane chamber itself. Due to the significantly larger footprint of the membrane, the membrane wafer Fluidic 1113 allows for the generation of larger volumes of plasma/serum. Depending on the blood sample, the achievable serum/plasma volume ranges from 20 μl to 35 μl. The Fluidic 783 combines a diamond shaped membrane with a round membrane, each with a 5 μl chamber.