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Cryogenic (Liquid Nitrogen) Vessel Temperature Monitoring Solutions
Proven, reliable performance down to -200 °C for temperature monitoring of liquid nitrogen tanks
API API APIs, freeze-dried substances and human samples must be transported and stored in the glass phase at the lowest possible temperature. Specialized cryogenic containers - dry liquid nitrogen tanks - can maintain temperatures at -196 °C with liquid nitrogen (LN2.) Because of the extremely low temperatures, monitoring temperature data in cryogenic containers is not only challenging, but also requires more complex processes, including pre-cooling and refilling with LN2.
The Importance of Temperature Monitoring of Liquid Nitrogen Tanks
Temperature testing during storage and transportation in liquid nitrogen tanks is very important for APIs, freeze-dried substances and human samples, and its importance is mainly realized in the following aspects:
1
Guaranteed Product Quality
Such biological samples or drugs are very sensitive to temperature and may change or even lose their activity under temperature fluctuation or out of the appropriate range. Through temperature testing, we can ensure that the temperature of the samples or drugs is stable during storage and transportation, thus ensuring the quality of the products.
2
Guaranteeing security
Some biological samples or pharmaceuticals may be very sensitive to temperature fluctuations, and high or low temperatures may affect their safety or even cause product contamination or harm. Through temperature testing, temperature abnormalities can be detected and avoided in time to ensure product safety.
3
Compliance Requirements
The storage and transportation of some pharmaceuticals and biological samples are subject to stringent regulations and standards, which often include requirements for temperature monitoring and recording. Temperature testing ensures compliance and avoids penalties or other legal issues.
4
Retrospective liability
When a product quality problem occurs, temperature testing can be traced back to temperature conditions throughout the storage and transportation process, helping to determine responsibility and cause, thereby improving storage and transportation management and reducing the likelihood of quality problems.
Difficulties in temperature monitoring of liquid nitrogen tanks
However, due to the special nature of liquid nitrogen, the difficulty in monitoring the temperature of liquid nitrogen tanks lies in how to ensure the accuracy and reliability of the temperature probe and the temperature recorder, as well as how to avoid data damage or loss.
- Extreme low temperature
The very low temperature of liquid nitrogen, typically around -196 degrees Celsius, means that temperature monitoring equipment and sensors need to be able to function and maintain accuracy at extremely low temperatures.
- Sealing performance
Liquid Nitrogen tanks are usually hermetically sealed, which means that the temperature monitoring equipment needs to be able to be safely placed in the tank and the sealing of the tank must not be compromised in a way that would affect the accuracy of the temperature monitoring.
- Data Transfer
When monitoring temperature in liquid nitrogen tanks, it is necessary to ensure that the temperature data can be reliably transmitted, and consideration needs to be given to maintaining the stability of data transmission, especially in special transportation environments.
- Equipment Reliability
Temperature monitoring equipment operating in extreme environments needs to be highly reliable and able to operate stably for long periods of time without failure, which poses a challenge to the design and selection of the monitoring equipment itself.
HONGKE complies with the Pharmaceutical Industry Code.
Liquid Nitrogen Tank Transportation and Storage Temperature Monitoring Solutions
In order to realize temperature monitoring, we can consider using temperature sensor/temperature probe or temperature recorder, which will be placed in liquid nitrogen tank and stored or transported together with the samples, and continuously record the temperature during the whole process. During the storage and transportation process, you can use liquid nitrogen special & stable temperature probe and cloud platform technology to realize real-time monitoring and recording of temperature, and alert the relevant personnel to take timely measures when problems or abnormalities occur.
HK-LIBERO CE
PDF/Bluetooth temperature logger with external probe
Temperature recorder with external probe, the temperature probe is introduced into the liquid nitrogen tank.
Suitable for low-temperature containers, customized temperature probe for liquid nitrogen tank applications
PDF/Bluetooth Temperature Recorder
GAMP® 5 and FDA 21 CFR Part 11 compliant
Coin cell battery powered, IATA compliant, safe for air transportation
Temperatures down to -200 °C
- Read PDF reports via computer USB interface or Bluetooth (phone APP).
- IQ-OQ templates for easy customer validation
- Configuration via USB or Bluetooth (phone APP)
- Multiple use (3 year battery life)
- Provide guidance and recommendations for installation on liquid nitrogen tanks
- Detailed analysis with elproVIEWER, compatible with liberoMANAGER
- Free calibration certificate
HK-LIBERO GE
Temperature logger with external probe for real-time transmission.
- Temperature recorder with external probe, the temperature probe is introduced into the liquid nitrogen tank.
- Suitable for low-temperature containers, customized temperature probe for liquid nitrogen tank applications
- Temperature logger with real-time transmission
- GAMP® 5 and FDA 21 CFR Part 11 compliant
- Dry-battery powered, IATA compliant, safe for air transportation
- Temperatures down to -200 °C and position and tilt can be measured
- Configuration via web interface
- Multiple use (14 month battery life)
- Real-time automatic readout and alerts via elproCLOUD cloud platform
- Detailed analysis via elproCLOUD cloud platform, compatible with liberoMANAGER
- IQ-OQ templates for easy customer validation
- Free calibration certificate
- Provide guidance and recommendations for installation on liquid nitrogen tanks
HK-LIBERO GF ext
Temperature logger with external probe for real-time transmission.
Suitable for refrigeration, ultra-low temperature and liquid nitrogen applications.
- Temperature logger with external probe, temperature probe into liquid nitrogen tank, freezer, dry ice
- Suitable for low-temperature containers, customized temperature probe for liquid nitrogen tank applications
- Real-Time Temperature Logger for Refrigeration, Freezing, Ultra Low Temperature and Liquid Nitrogen Applications
- GAMP® 5 and FDA 21 CFR Part 11 compliant
- Temperatures down to -200 °C and position and tilt can be measured
- Includes a lithium metal battery to ensure operation in low temperature environments down to -35°C.
- Configuration via web interface
- Multiple use (14 month battery life)
- Real-time automatic readout and alerts via elproCLOUD cloud platform
- Detailed analysis via elproCLOUD cloud platform, compatible with liberoMANAGER
- IQ-OQ templates for easy customer validation
- Free calibration certificate
- Provide guidance and recommendations for installation on liquid nitrogen tanks
Completion of aviation safety certification for safe air transportation
All of the above temperature recorders/indicators supplied by Hongke for vaccine transportation are powered by button cell batteries, compliant with IATA regulations, and are certified as safe for air transportation by the Shanghai Institute of Chemical Technology's Certificate of Cargo Transportation Conditions and Beijing DGM Air Transportation Hazard Identification Report Dieter Ziehm.
Professional technical support from HONGKEI to help you succeed in your project.
As a provider specializing in biotechnology solutions, Avision is committed to providing you with a range of paid technical services related to this product that are designed to help your project succeed in the most cost-effective manner. If you are in need of product-related technical services, please contact us!
