High-value novel biopharmaceuticals have extremely stringent cold chain temperature control requirements; even the slightest temperature deviation can result in losses of tens of millions of yuan and pose compliance risks. Using the example of a major domestic pharmaceutical group’s implementation of Hongke’s ELPRO LIBERO series temperature loggers, this article provides an in-depth analysis of how the system achieves zero-incident temperature control throughout the entire process (2°C to 8°C) and dual compliance with GSP and international standards through the automatic generation of tamper-proof PDF reports, SmartStart batch configuration, and standardized SOP services.